Our Scientific Foundation

Definition and Scope of Prebiotics

This paper redefines what prebiotics are, expanding beyond just fibers to include a broader range of compounds. It clarifies that prebiotics are substances selectively used by beneficial microbes to improve health.

The Interplay Between Diet and the Gut Microbiome

This comprehensive review explains how different diets—from Mediterranean to Western—shape the gut microbiome, and how these dietary-microbe interactions affect metabolic health, immunity, and disease risk.

Host and Microbiota Metabolic Signals in Ageing and Longevity

This review details how the metabolic dialogue between host and microbes changes over time. It explores how gut microbes can influence lifespan by modulating inflammation, mitochondrial function, and nutrient-sensing pathways.

Shaping the Future of Probiotics and Prebiotics

A broad, visionary review of where the fields of probiotics and prebiotics are heading. It explores new microbial candidates, mechanisms of action, regulatory trends, and how precision nutrition is shaping next-gen products like synbiotics and postbiotics.

Roles of the Gut Microbiome in Weight Management

The gut microbiome plays a critical role in how our bodies gain or lose weight. This paper explores how microbes influence energy balance, appetite, and fat storage—and how they may be harnessed for better long-term weight control.

The Gut Microbiota–Brain Axis in Behaviour and Disorders

This review unpacks how gut bacteria influence brain development and function. It connects microbial activity to mood, cognition, and disorders like autism and depression, highlighting the gut–brain axis as a promising target for future therapies.

Diet–Microbiota Interactions and Personalized Nutrition

This review explores how diet affects each person's microbiome in unique ways. It explains that a "one-size-fits-all" approach to nutrition doesn’t work, but rather, personalised diets based on your microbiome could improve health.

Impact on the Pathogenesis of Obesity and Beyond

This article examines how alterations in the gut microbiome contribute to obesity and its complications, including diabetes and metabolic syndrome. It discusses microbial mechanisms that affect fat storage, insulin sensitivity, and inflammation.

The Gut Microbiome as a Modulator of Healthy Ageing

Ageing alters the microbiome, but the microbiome also influences how we age. This paper explores how specific microbes and their metabolites can support healthier ageing and help prevent age-related diseases like frailty and cognitive decline.